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Purpurogallin

SKU: orb1307831

Description

Purpurogallin is a natural phenol from Quercus spp. with potent xanthine oxidase inhibition (IC50: 0.2 μM). It serves as a valuable research tool for studying oxidative stress and inflammation, with applications in both in vitro enzyme assays and in vivo models of hyperuricemia and related disorders.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number569-77-7
MW220.18
Purity96.44%
FormulaC11H8O5
SMILESOc1cc2cccc(O)c(=O)c2c(O)c1O
TargetXanthine Oxidase
SolubilityDMSO:125 mg/mL (567.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (18.17 mM)

Bioactivity

Target IC50
XO:0.2 μM
In Vivo
By the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression, Purpurogallin (100-400 μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect .
In Vitro
Purpurogallin (100 μM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells. Purpurogallin (50 or 100 μM; 7 or 25 hours; BV2 murine microglial cells) treatment decreases the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, Xanthine Oxidase, xanthine oxidase, XanthineOxidase, Purpurogallin

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Key Properties

No computed properties available.

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Purpurogallin (orb1307831)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 130.00
25 mg
$ 170.00
50 mg
$ 210.00
100 mg
$ 290.00
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