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PX20606

SKU: orb2564340

Description

PX20606 is an orally active farnesoid X receptor (FXR) agonist, demonstrating EC50 values of 220 nM (mFXR) and 50 nM (hFXR) in Gal4-FXR assays. It induces the expression of the tumor suppressor gene NDRG2 and inhibits tumor growth and metastasis in a mouse HCC model. Additionally, PX20606 exhibits hepatoprotective properties.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1268245-19-7
MW554.85
FormulaC29H22Cl3NO4
SMILESO=C(O)C1=CC=C(C=C1)C2CC2C3=CC=C(OCC=4C(=NOC4C5CC5)C=6C(Cl)=CC=CC6Cl)C=C3Cl
TargetFXR

Storage & Handling

Storage-20°C
DisclaimerFor research use only

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PX20606 (orb2564340)

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