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QNZ

SKU: orb1300983

Description

QNZ (EVP4593) is a potent small molecule inhibitor of NF-κB activation and TNF-α production, with respective IC50 values of 11 nM and 7 nM. It is widely used in research to study inflammatory signaling pathways and has been applied in both cellular and animal models of inflammation and autoimmune disease.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number545380-34-5
MW356.42
Purity99.86%
FormulaC22H20N4O
SMILESNc1ccc2ncnc(NCCc3ccc(Oc4ccccc4)cc3)c2c1
TargetTNF,NF-κB
SolubilityDMSO:250 mg/mL (701.42 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.81 mM)

Bioactivity

Target IC50
TNF-α:7 nM|NF-κB:11 nM (in human Jurkat cells transfected with pNFκB-Luc)
In Vivo
In murine spleen cells stimulated by lipopolysaccharide, EVP4593 (IC50= nM) inhibits the production of TNF-α. In rat neutrophils, EVP4593 (10 nM) suppresses the upregulation of CSE expression induced by lipopolysaccharide. EVP4593 (40 nM) entirely inhibits the increase in the number and length of axons during laminin treatment in Schwann cell adhesion. Additionally, in IB4-negative neurons, EVP4593 (100 nM) blocks the induction effect of GRO/KC on K currents.
In Vitro
Intraperitoneal injection of EVP4593 (1 mg/kg) in rats suppressed carrageenan-induced paw edema in a dose-dependent manner.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CAY10470, CAY-10470, CAY 10470, NF-κB, NFκB, NFkB, NF-kB, Nuclear factor-κB, Nuclear factor-kappaB, inhibit, EVP 4593, EVP4593, EVP-4593, Inhibitor, Tumor Necrosis Factor Receptor, TNF-α, TNFR, TNF Receptor, QNZ

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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QNZ (orb1300983)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
2 mg
$ 100.00
5 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 190.00
25 mg
$ 240.00
50 mg
$ 390.00
100 mg
$ 560.00
200 mg
$ 790.00
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