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QNZ

SKU: orb1300983

Description

QNZ (EVP4593) is a potent small molecule inhibitor of NF-κB activation and TNF-α production, with respective IC50 values of 11 nM and 7 nM. It is widely used in research to study inflammatory signaling pathways and has been applied in both cellular and animal models of inflammation and autoimmune disease.

Research Area

Neuroscience

Images & Validation

Key Properties

CAS Number545380-34-5
MW356.42
Purity>98%
FormulaC22H20N4O
SMILESNc1ccc2ncnc(NCCc3ccc(Oc4ccccc4)cc3)c2c1
TargetTNF,NF-κB
SolubilitySoluble in DMSO (up to 20 mg/ml)

Bioactivity

Target IC50
TNF-α:7 nM|NF-κB:11 nM (in human Jurkat cells transfected with pNFκB-Luc)
In Vivo
In murine spleen cells stimulated by lipopolysaccharide, EVP4593 (IC50= nM) inhibits the production of TNF-α. In rat neutrophils, EVP4593 (10 nM) suppresses the upregulation of CSE expression induced by lipopolysaccharide. EVP4593 (40 nM) entirely inhibits the increase in the number and length of axons during laminin treatment in Schwann cell adhesion. Additionally, in IB4-negative neurons, EVP4593 (100 nM) blocks the induction effect of GRO/KC on K currents.
In Vitro
Intraperitoneal injection of EVP4593 (1 mg/kg) in rats suppressed carrageenan-induced paw edema in a dose-dependent manner.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

EVP4593

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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QNZ (orb1300983)

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5 mg
$ 190.00
25 mg
$ 360.00
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