Quercetin

SKU: orb1306219

Description

Quercetin is a natural flavonoid that acts as a SIRT1 activator and a PI3K inhibitor (γ, δ, β isoforms). It also functions as a heat shock protein (Hsp70/Hsp90) inhibitor, reducing exosome release, making it a valuable tool for research in aging, oncology, and inflammation in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	117-39-5
MW	302.24
Purity	99.98% (May vary between batches)
Formula	C₁₅H₁₀O₇
SMILES	O=C1C(O)=C(OC=2C=C(O)C=C(O)C12)C=3C=CC(O)=C(O)C3
Target	PI3K,Autophagy,ROS,Reactive Oxygen Species,Mitophagy,Apoptosis
Solubility	DMSO:230 mg/mL (760.98 mM);10% DMSO + 50% peg 300 + 5% Tween +35% Saline:10 mg/mL (33.09 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:4 mg/mL (13.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5.7 mg/mL (18.86 mM)

Customer Validated Data

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The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this product works for your specific application or species, even if we haven't tested it ourselves.

Success by Application

Reactivity Distribution

Latest Experiments

1 Results

Dilution

Sample

Summary

In vitro

Human

Human UM cell lines

Dissolved in DMSO to prepare a...

Bioactivity

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Target IC50	PI3Kβ:5.4 μM\|PI3Kγ:2.4 μM\|PI3Kδ:3.0 μM
In Vivo	Quercetin inhibits TNF-induced LDH release, reduces EC-dependent adhesion of neutrophils to bovine pulmonary artery endothelial cells (BPAEC), and also suppresses DNA synthesis and cell proliferation in these cells. As a PI3K inhibitor (IC50=2.4 - 5.4 μM), quercetin strongly inhibits PI3K and Src kinases, moderately inhibits Akt1/2, and has a slight effect on PKC, p38, and ERK1/2.
In Vitro	In xenografts of human prostate cancer LNCaP and PC-3 cells, the combined administration of Quercetin (75 mg/kg) and 2-methoxyestradiol effectively inhibits tumor growth.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Sophoretin, Quercetin, ReactiveOxygenSpecies, PI3K, Reactive Oxygen Species, Phosphoinositide 3-kinase, PI3Kδ, PI3Kγ, Apoptosis, Autophagy, Inhibitor, Mitochondrial Autophagy, Mitophagy, inhibit

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

5280343 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Reactivity:	Mouse
Dynamic Range:	0.79-50ng/mL
Sensitivity:	0.47 ng/mL

Reactivity:	Human
Dynamic Range:	62.5-4000pg/mL
Sensitivity:	37.5 pg/mL

Applications:	ELISA, IF, IHC
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, IHC, WB
Reactivity:	Human
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Quercetin

Description

Research Area

Images & Validation

Key Properties

Customer Validated Data

Success by Application

Reactivity Distribution

Latest Experiments

Bioactivity

Storage & Handling

Alternative Names

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Compound Identifiers

Key Properties

Protocol Information

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