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R-10015

SKU: orb1309194

Description

R-10015 is a potent and selective LIMK inhibitor that targets the ATP-binding pocket, exhibiting an IC50 of 38 nM against human LIMK1. Its application in research includes the study of cytoskeletal dynamics and investigation of its broad-spectrum antiviral properties, including potential roles in HIV infection studies.

Research Area

Cell Biology, Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number2097938-51-5
MW410.86
Purity98.97%
FormulaC20H19ClN6O2
SMILESCOC(=O)c1ccc2nc([nH]c2c1)C1CCN(CC1)c1ncnc2[nH]cc(Cl)c12
TargetLIM Kinase,Reverse Transcriptase
SolubilityDMSO:62.5 mg/mL (152.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.17 mM)

Bioactivity

Target IC50
LIMK1 (human):38 nM
In Vitro
R10015 as a lead compound that blocks LIMK activity by binding to the ATP-binding pocket. R10015 specifically blocks viral DNA synthesis, nuclear migration, and virion release. In addition, R10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1), suggesting that LIMK inhibitors could be developed as a new class of broad-spectrum antiviral drugs.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, human LIMK1, inhibit, LIMKinase, LIMKs, LIM Kinase, LIM Kinase (LIMK), Reverse Transcriptase, ReverseTranscriptase, R 10015, R-10015, R10015

Similar Products

  • R-10015 [orb1219750]

    >98% (HPLC)

    2097938-51-5

    410.86

    C20H19ClN6O2

    1 g, 2 mg, 25 mg, 5 mg, 10 mg, 50 mg, 500 mg, 100 mg
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Key Properties

No computed properties available.

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Protocol Information

R-10015 (orb1309194)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 230.00
25 mg
$ 360.00
50 mg
$ 460.00
100 mg
$ 630.00
200 mg
$ 840.00
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