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R-7050

SKU: orb1302694

Description

R-7050 (TNF-α Antagonist III) is a selective small molecule antagonist of tumor necrosis factor alpha (TNFα). It is utilized in research to study TNFα-mediated pathways in inflammatory and autoimmune diseases, with applications in both cellular (in vitro) and animal (in vivo) experimental models.

Research Area

Cell Biology

Images & Validation

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R-7050

Key Properties

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CAS Number303997-35-5
MW380.77
Purity99.80%
FormulaC16H8ClF3N4S
SMILESC(F)(F)(F)C=1N2C(C(SC3=CC=CC=C3)=NC=4C2=CC(Cl)=CC4)=NN1
TargetTNF
SolubilityDMSO:10 mg/mL (26.26 mM);10% DMSO+90% Corn Oil:1 mg/mL (2.63 mM)

Bioactivity

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In Vivo
Administered at doses of 6 mg/kg, R-7050 significantly attenuates Evans blue extravasation in brain tissue to 28.7±5.9 μg and 30.3±1.9 μg when given 0.5 hours or 2 hours after induced intracerebral hemorrhage (ICH), respectively, presenting statistical significance (p<0.05 and p<0.01 vs ICH, respectively) and comparability to sham-operated controls. Concurrently, brain water content, indicative of brain edema, increases markedly from 75.6±0.3% in sham to 81.5±0.5% post-ICH (p<0.05 vs. sham). Doses of R-7050 (6, 12, or 18 mg/kg) effectively reduce the brain water content to 78.5±0.3%, 78.3±0.3%, and 79.3±0.5%, respectively, each significantly against ICH (p<0.05) and with no significant difference among the dosages. However, a notable decrease in general activity/locomotion is observed with the highest dose (18 mg/kg). R-7050, at a 6 mg/kg dosage, also significantly mitigates the increase in brain water content post-ICH to levels akin to those in sham-operated mice (p<0.05 vs ICH and not significantly different from sham), demonstrating its potential in reducing both brain edema and permeability post-ICH when administered timely.
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In Vitro
R-7050 is a cell-permeable triazoloquinoxaline compound that selectively inhibits TNF-α induced cellular signaling. Unlike biologic TNF inhibitors (e.g. Infliximab, Etanercept, Adalimumab) that directly bind TNF-α and function as decoy receptors, R-7050 does not affect binding of TNF-α to TNFR. In contrast, R-7050 selectively inhibits the association of TNFR with intracellular adaptor molecules (e.g. TRADD, RIP), limits receptor internalization, and prevents subsequent cellular responses after TNF-α binding.
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Inhibitor, inhibit, Tumor Necrosis Factor Receptor, TNF-α, TNF-α Antagonist III, TNF Receptor, TNFR, TNF-alpha Antagonist III, TNF-a Antagonist III, R 7050, R7050, R-7050

Similar Products

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  • R-7050

    R-7050 [orb1222391]

    >98% (HPLC)

    303997-35-5

    380.77

    C16H8ClF3N4S

    1 g, 500 mg, 5 mg, 10 mg, 25 mg, 100 mg, 50 mg, 2 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
1486608 ↗

Key Properties

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No computed properties available.

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R-7050 (orb1302694)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 70.00
2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 110.00
5 mg
$ 110.00
10 mg
$ 140.00
25 mg
$ 260.00
50 mg
$ 340.00
100 mg
$ 530.00
200 mg
$ 740.00
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