RecombinantFGF-18,Human

SKU: orb1494884

Description

Fibroblast Growth Factor-18 (FGF-18) is a heparin-binding growth factor that is a member of the FGF family. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. FGF-18 plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. FGF-18 is required for normal ossification and bone development. It can also stimulate hepatic and intestinal proliferation.Recombinant human Fibroblast Growth Factor-18 (rhFGF-18) produced in E.coli is a single non-glycosylated polypeptide chain containing 174 amino acids. A fully biologically active molecule, rhFGF-18 has a molecular mass of 20.3 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.

Images & Validation

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Application Notes	Reconstituted in ddH2O at 100 μg/ml.

Key Properties

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Source	Escherichia coli.
Biological Activity	ED50 1.0× 10ˆ5units/mg.
Molecular Weight	20.3 kDa, observed by reducing SDS-PAGE.
Protein Sequence	MAEENVDFR IHVENQTRAR DDVSRKQLRL YQLYSRTSGK HIQVLGRRIS ARGEDGDKYA QLLVETDTFG SQVRIKGKET EFYLCMNRKG KLVGKPDGTS KECVFIEKVL ENNYTALMSA KYSGWYVGFT KKGRPRKGPK TRENQQDVHF MKRYPKGQPE LQKPFKYTTV TKRSR
Purification	> 95% by SDS-PAGE and HPLC analyses.
Purity	> 95% by SDS-PAGE and HPLC analyses.
Endotoxins	< 0.2 EU/μg, determined by LAL method.

Storage & Handling

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Storage	Lyophilized recombinant human Fibroblast Growth Factor-18 (rhFGF-18) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFGF-18 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Form/Appearance	Lyophilized after extensive dialysis against PBS.
Buffer/Preservatives	Lyophilized after extensive dialysis against PBS.
Disclaimer	For research use only

Alternative Names

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FGF18, Fibroblast Growth Factor-18, zFGF5, FGFI

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