Remdesivir

SKU: orb1299527

Description

Remdesivir (GS-5734) is a broad-spectrum antiviral nucleoside analog prodrug that inhibits viral RNA-dependent RNA polymerase. It has demonstrated in vitro and in vivo activity against Ebola, SARS, MERS, and SARS-CoV-2 viruses, supporting its research use for coronavirus and filovirus studies.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	1809249-37-3
MW	602.58
Purity	>99.99%
Formula	C₂₇H₃₅N₆O₈P
SMILES	C(#N)[C@]1(O[C@H](COP(OC2=CC=CC=C2)(N[C@H](C(OCC(CC)CC)=O)C)=O)[C@@H](O)[C@H]1O)C=3N4C(=CC3)C(N)=NC=N4
Target	DNA/RNA Synthesis,SARS-CoV

Bioactivity

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Target IC50	Caco-2 cells:0.76 μM\|MERS-CoV:74 nM (EC50)\|SARS-CoV-2:0.77 μM (EC50)\|HeLa cells:0.1 μM (EC50)\|HEp-2 cells:0.11 μM\|SARS-CoV:74 nM (EC50)\|Vero cells C1008:0.62 μM (EC50)\|MHV:0.03 µM (EC50) Read more...
In Vivo	METHODS: To assay antiviral activity in vivo, Remdesivir (25 mg/kg, 12% sulfobutylether-β-cyclodextrin sodium salt in water (with HCl/NaOH) at pH 5.0) was injected subcutaneously into MERS-CoV-infected Ces1c-/- hDPP4 mice twice daily. RESULTS: Prophylactic Remdesivir reduced MERS-CoV replication and disease. METHODS: To assay antiviral activity in vivo, Remdesivir (25 mg/kg once daily, administered three times) and Loratadine (10 mg/kg once daily, administered four times) were administered intraperitoneally to 501Y.V2 SARS-CoV-2 infected BALB/c mice. RESULTS: The combination of Remdesivir and the antihistamine Loratadine reduced SARS-CoV-2 replication and inflammation and protected against lung injury. Read more...
In Vitro	METHODS: Mouse hepatitis virus (MHV)-infected DBT cells were incubated with Remdesivir (0.01-1 µM) for 24 h, and the supernatant was analyzed for viral titer by plaque assay. RESULTS: Remdesivir effectively inhibited MHV with an EC50 of 0.03 µM. METHODS: 2019-nCoV-infected Vero E6 cells were treated with Remdesivir (0-400 µM) for 48 h. Viral yield in cell supernatants was detected using qRT-PCR. RESULTS: Remdesivir effectively blocked viral infection at low micromolar concentrations and showed high SI (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87). Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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2019-nCoV, antiviral, COVID-19, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis, infection, inhibit, Inhibitor, MERS-CoV, GS5734, GS-5734, GS 5734, SARSCoV, SARS coronavirus, SARS-CoV, RNA Synthesis, RNASynthesis, Remdesivir

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Compound Identifiers

PubChem CID

56832851 ↗

Key Properties

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No computed properties available.

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Remdesivir (orb1299527)

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MW:	334.775
Formula:	C₁₇H₁₆ClFN₂O₂

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MW:	371.24
Formula:	C₁₂H₁₄N₅O₇P

Remdesivir

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Remdesivir (orb1299527)

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