Resiniferatoxin

SKU: orb1695494

Description

Resiniferatoxin is a potent synthetic TRPV1 agonist with significant anti-inflammatory properties, suppressing the production of pro-inflammatory cytokines such as IL-12, IFN-γ, and TNF-α. It is widely used in neuroscience and immunology research to study pain pathways and inflammatory responses in both cellular and animal models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	57444-62-9
MW	628.71
Purity	99.34%
Formula	C₃₇H₄₀O₉
SMILES	C[C@H]1[C@]23[C@]([C@@]4([C@](C(C)=C)(C1)O[C@](CC5=CC=CC=C5)(O2)O4)[H])(C=C(COC(CC6=CC(OC)=C(O)C=C6)=O)C[C@@]7(O)[C@]3(C=C(C)C7=O)[H])[H]
Target	TRP/TRPV Channel,IL Receptor
Solubility	DMSO:32 mg/mL (50.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.59 mM)

Bioactivity

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In Vivo

METHODS: Resiniferatoxin ((+)-Resiniferatoxin) (2 μg/10 μl) was injected intrathecally into the T2/T3 space of mice. Cardiac sympathetic nerve activity (CSNA) and cardiac electrophysiology were assessed two weeks later. RESULTS Intrathecal injection of Resiniferatoxin ((+)-Resiniferatoxin) significantly and selectively eliminated the expression of dorsal horn afferent markers (TRPV1 and calcitonin gene-related peptide) and reduced overactive CSNA. Electrophysiological studies have shown that intrathecal administration of Resiniferatoxin ((+)-Resiniferatoxin) can significantly reverse the prolongation of action potential duration (APD) and APD alternating hormones and reduce the inducibility of ventricular arrhythmias.

Storage & Handling

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Storage	store at low temperature,keep away from direct sunlight,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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[3H]resiniferatoxin, ILReceptor, IL Receptor, RTX, Resiniferatoxin, Resiniferatoxin (From Euphorbia), Th1 cytokine

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Compound Identifiers

PubChem CID

5702546 ↗

Key Properties

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No computed properties available.

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