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Rifaximin

SKU: orb1309584

Description

Rifaximin

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Images & Validation

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Rifaximin

Key Properties

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CAS Number80621-81-4
MW785.88
Purity99.38%
FormulaC43H51N3O11
SMILESCOC1\C=C/OC2(C)OC3=C(C2=O)C2=C(C(O)=C3C)C(O)=C(NC(=O)\C(C)=C/C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C1=C2N=C2C=C(C)C=CN12
TargetDNA/RNA Synthesis,Antibiotic,Antibacterial
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (3.18 mM);Ethanol:3 mg/mL (3.82 mM);DMSO:50 mg/mL (63.62 mM)

Bioactivity

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In Vivo
Rifaximin exhibits broad-spectrum activity against aerobic and anaerobic Gram-positive and Gram-negative microorganisms.Rifaximin exhibits a low MIC against Gram-positive bacteria, with a dose range of 0.01 μg/mL to 0.5 μg/mL for MIC 90.Rifaximin binds to the β-subunit of the bacterial DNA-dependent RNA polymerase and inhibits the start of the chain of RNA synthesis. Rifaximin inhibits LPS-induced cytokine and chemokine expression by inhibiting NF-κB DNA binding activity.50 μM Rifaximin reduces changes in pro-inflammatory factor production induced by LPS stimulation in the IEC, such as TNF-α, IL-8, Rantes, and PGE2 in normal intestinal epithelial cells.100 μM Rifaximin is also shown to inhibit LPS-induced cytokine expression by inhibiting NF-κB DNA binding activity. μM Rifaximin effectively reduced the expression of TNFα, IL-8, MIP-3α and RANTES by lipopolysaccharide-induced stimulation.
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In Vitro
Rifaximin exhibits broad-spectrum activity against aerobic and anaerobic Gram-positive and Gram-negative microorganisms.Rifaximin exhibits a low MIC against Gram-positive bacteria, with a dose range of 0.01 μg/mL to 0.5 μg/mL for MIC 90.Rifaximin binds to the β-subunit of the bacterial DNA-dependent RNA polymerase and inhibits the start of the chain of RNA synthesis. Rifaximin inhibits LPS-induced cytokine and chemokine expression by inhibiting NF-κB DNA binding activity.50 μM Rifaximin reduces changes in pro-inflammatory factor production induced by LPS stimulation in the IEC, such as TNF-α, IL-8, Rantes, and PGE2 in normal intestinal epithelial cells.100 μM Rifaximin is also shown to inhibit LPS-induced cytokine expression by inhibiting NF-κB DNA binding activity. μM Rifaximin effectively reduced the expression of TNFα, IL-8, MIP-3α and RANTES by lipopolysaccharide-induced stimulation.
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Storage & Handling

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Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Antibiotic, Bacterial, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, diarrhea, inhibit, infection, gastrointestinal, Inhibitor, RNASynthesis, RNA Synthesis, Rifaximin

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
42608884 ↗

Key Properties

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No computed properties available.

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Rifaximin (orb1309584)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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200 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 100.00
500 mg
$ 100.00
1 g
$ 130.00
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