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RJW100

SKU: orb1691846

Description

RJW100 is a potent small molecule agonist of nuclear receptors LRH-1 (NR5A2) and SF-1 (NR5A1), with pEC50 values of 6.6 and 7.5, respectively. It also activates the miR-200c promoter, making it a useful research tool for studying metabolism, steroidogenesis, and epithelial-mesenchymal transition in cellular models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1276664-20-0
MW386.57
Purity99.45% (May vary between batches)
FormulaC28H34O
SMILESC(=C)([C@]12C(=C(CCCCCC)C[C@]1([C@H](O)CC2)[H])C3=CC=CC=C3)C4=CC=CC=C4
TargetOrphan Receptor,MicroRNA,Others
SolubilityDMSO:55 mg/mL (142.28 mM)

Bioactivity

In Vitro
RJW100 (compound 24-exo) treatment significantly increases small/short heterodimer partner (SHP) transcripts in a dose-dependent manner starting at 5 µM. It almost completely displaces bound PIP2 phospholipid from SF-1 at 1 µM. Using hLRH-1 LBD alone without any phospholipids, a clear dose-dependent shift in hLRH-1 LBD native PAGE migration is observed with RJW100 (compound 24-exo; 0-100 µM) binding. RJW100 strongly activates the miR-200c promoter and effectively downregulates ZEB1 and ZEB2 proteins.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

liver receptor homolog-1 (LRH1, NR5A2), steroidogenic factor-1 (SF-1, NR5A1), RJW 100, RJW100, RJW-100

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 290.00
5 mg
$ 640.00
1 ml x 10 mM (in DMSO)
$ 660.00
10 mg
$ 910.00
25 mg
$ 1,310.00
DispatchUsually dispatched within 5-10 working days
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