RO2959 Hydrochloride

SKU: orb1298569

Description

RO2959 Hydrochloride is a selective CRAC channel inhibitor with an IC50 of 402 nM and a potent suppressor of human IL-2 production. This compound is a valuable research tool for studying T-cell activation and calcium signaling in both cellular and animal models of immune dysfunction.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1219927-22-6
MW	463.93
Purity	99.24% (May vary between batches)
Formula	C₂₁H₂₀ClF₂N₅OS
SMILES	Cl.Cc1cnc(s1)N1CCC(C)=C(C1)c1cnc(NC(=O)c2c(F)cccc2F)cn1
Target	IL Receptor,Interleukin,Calcium Channel
Solubility	DMSO:10 mg/mL (21.55 mM)

Bioactivity

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Target IC50

CRAC channel:402 nM|Orai2/STIM1:25 nM

In Vitro

RO2959 is a potent SOCE inhibitor that blocked an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either TCR stimulation or thapsigargin treatment. RO2959 completely inhibited cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction).

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CRAC Channel, CRAC channel, CalciumChannel, Calcium Channel, Calcium release-activated channels, Ca2+ release-activated Ca2+ channels, anti-proliferation, failure, heart, Inhibitor, Interleukin Related, Interleukin, IL Receptor, Orai1, inhibit, ILReceptor, IL-2, IP3, RO 2959, RO 2959 Hydrochloride, RO2959, RO-2959, RO2959 HCl, RO2959 Hydrochloride, RO-2959 Hydrochloride, SOCE, Stim1, T-cell

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

45274292 ↗

Key Properties

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No computed properties available.

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