Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

Ropinirole

SKU: orb1689604

Description

Ropinirole (SKF 101468) is a potent and orally active D3/D2 dopamine receptor agonist. It is widely used in Parkinson's disease research and has been investigated in preclinical models for its potential neuroprotective effects in amyotrophic lateral sclerosis (ALS).

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

−
Ropinirole

Key Properties

−
CAS Number91374-21-9
MW260.38
Purity99.80% (May vary between batches)
FormulaC16H24N2O
SMILESO=C1NC2=CC=CC(=C2C1)CCN(CCC)CCC
TargetDopamine Receptor

Bioactivity

−
Target IC50
D4 receptor (human):6.8 (pEC50)|D2 receptor:29 nM (Ki)|D2 receptor (human):7.4 (pEC50)|D3 receptor (human):8.4 (pEC50)
In Vivo
Intraperitoneal injections of Ropinirole at doses of 0.1-10 mg/kg were able to lower the threshold for intracranial self-stimulation (ICSS), showing anxiolytic and antidepressant effects without affecting motor function or spatial memory.
In Vitro
Ropinirole has a 10- to 20-fold higher binding affinity for D3 receptors than for D2 and D4 receptors. As an orally potent D3/D2 receptor agonist, Ropinirole has a Ki value of 29 nM for the D2 receptor and has pEC50s of 7.4, 8.4, and 6.8 for the hD2, hD3, and hD4 receptors, respectively, with no affinity for the D1 receptor. Ropinirole showed low activity at α2-adrenergic receptors and 5-HT2 receptors, but no activity at 5-HT1 receptors, benzodiazepine receptors, γ-aminobutyric acid receptors, and α1 and β-adrenergic receptors.

Storage & Handling

−
Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
DopamineReceptor, Dopamine Receptor, D2, D3, SKF 101468, SKF101468

Similar Products

−
  • Ropinirole hydrochloride

    Ropinirole hydrochloride [orb1305289]

    99.98% (May vary between batches)

    91374-20-8

    296.84

    C16H24N2O·HCl

    25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 ml x 10 mM (in DMSO)
  • Ropinirole impurity 10

    Ropinirole impurity 10 [orb3215840]

    2734474-99-6

    289.37

    C16H23N3O2

    50 mg, 10 mg
  • Ropinirole impurity 3

    Ropinirole impurity 3 [orb3214637]

    1027600-42-5

    290.40

    C17H26N2O2

    10 mg, 50 mg
  • Ropinirole impurity 5

    Ropinirole impurity 5 [orb3214850]

    920755-10-8

    278.39

    C16H26N2O2

    10 mg, 50 mg
  • Ropinirole impurity 11

    Ropinirole impurity 11 [orb3214769]

    249622-60-4

    260.37

    C16H24N2O

    50 mg, 10 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
5095 ↗

Key Properties

−
No computed properties available.

Protocol Information

Find More Protocols

Available Sizes

Select a size below

25 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 80.00
50 mg
$ 100.00
100 mg
$ 120.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry
Need technical support? Find your Distributor Return and Tax Policy

Email

info@biorbyt.com

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

biorbyt.com/distributor