RWJ52353 hydrochloride

SKU: orb2565336

Description

RWJ-52353 hydrochloride is a potent oral agonist of the α2D adrenergic receptor (Ki: 1.5 nM) with potential analgesic properties. It exhibits pain-relief activity in abdominal tests on rats and mice and reduces agitation in mice during the hot plate and tail flick tests. Furthermore, RWJ-52353 hydrochloride modulates the organic cation transporter (OCT) subtypes by inhibiting rOCT1 and rOCT2 with IC50 values of 100 μM and 20 μM, respectively, and activating rOCT3, influencing the transport of [3H]-1-methyl-4-phenylpyridinium ([3H]MPP) in cells.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	245744-13-2
Formula	C₁₁H₁₁ClN₂S
SMILES	C=12C(=CCCC1SC=C2)C3=CN=CN3.Cl
Target	Adrenergic Receptor

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

Adrenergic Receptor

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