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(S)-AMPA HCl

SKU: orb2695163

Description

(S)-AMPA hydrochloride is a selective agonist for AMPA-type glutamate receptors. It is utilized in neuroscience research, including in vitro electrophysiology and in vivo studies exploring its potential antidepressant-like effects and role in Parkinson's disease models.

Research Area

Neuroscience

Images & Validation

Key Properties

MW222.63
Purity99.18% (May vary between batches)
FormulaC7H11ClN2O4
SMILESCl.Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
TargetGluR
SolubilityH2O:25 mg/mL (112.29 mM)

Bioactivity

Target IC50
AMPA:3.1 μM (EC50)
In Vivo
Single focal injection of the (S)-AMPA HCl(6 nmol/microliters) into rat dorsal hippocampus resulted in widespread neurodegeneration with 90-100% loss of hippocampal pyramidal cells in CA1, CA2, CA3 and CA4 subfields, and 50-70% loss of dentate granule (DG) cells.
In Vitro
(S)-AMPA HCl is a potent and selective AMPA receptor agonist. (S)-AMPA HCl (1 μM) infusion significantly reduced CGRP release in a CB-dependent manner. In cultured mouse cortical neurons, (S)-AMPA HCl induces apoptotic states such as cell contraction, neurite vesicles and nuclear enrichment, with an EC50 of 3.1 μM.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

(S)-AMPA HCl(83643-88-3 Free base), (S)AMPAHCl(83643883Freebase), L-AMPA HCl
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Key Properties

No computed properties available.

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Protocol Information

(S)-AMPA HCl (orb2695163)

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Available Sizes

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1 mg
$ 300.00
5 mg
$ 610.00
10 mg
$ 890.00
25 mg
$ 1,470.00
50 mg
$ 2,180.00
DispatchUsually dispatched within 5-10 working days
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