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S-(+)-Marmesin

SKU: orb1301517

Description

S-(+)-Marmesin is a natural coumarin compound with dual inhibitory activity against COX-2 and 5-LOX enzymes. It is a useful research tool for studying inflammation pathways and has been investigated in both in vitro and in vivo models for its potential pharmacological effects.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience

Images & Validation

Key Properties

CAS Number13849-08-6
MW246.26
Purity98.00%
FormulaC14H14O4
SMILESCC(C)(O)[C@@H]1Cc2cc3ccc(=O)oc3cc2O1
TargetCOX,Lipoxygenase
SolubilityDMSO:2 mg/mL (8.12 mM)

Bioactivity

In Vivo
Marmesin inhibits colony formation and induces apoptosis dose-dependently.Marmesin treatment triggered upregulation of Bax and downregulation of Bcl-2 causing significant increase in the Bax/Bcl-2 ratio, marmesin could also induce ROS mediated alterations in mitochondrial membrane potential. Additionally, marmesin induced G2/M cell cycle arrest and significantly inhibited cell migration potential of leukemia cells at the IC50. Remarkably, marmesin prevent tumor growth significantly in vivo at the dosage of 30 mg/kg in vivo. These results strongly indicate that marmesin may prove to be a novel anticancer lead for the management of leukemia.
In Vitro
Marmesin treatment abrogated VEGF-A-induced endothelial cell migration, invasion and capillary-like structure formation in vitro as well as angiogenic sprouting ex vivo. These anti-angiogenic activities of marmesin were mediated through inactivation of VEGF-A-stimulated signaling pathways, and down-regulation of cell surface signaling molecules including VEGF receptor-2, human epidermal growth factor receptor-2, integrin β1 and integrin-liked kinase.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

marmesin, Inhibitor, Lipoxygenase, inhibit, LOX, COX-2, COX, Cyclooxygenase, (S)-Marmesin, (+)-Marmesin, 5-Lipoxygenase, S-Marmesin, S (+) Marmesin, S(+)Marmesin

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Key Properties

No computed properties available.

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Protocol Information

S-(+)-Marmesin (orb1301517)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 70.00
5 mg
$ 110.00
10 mg
$ 140.00
25 mg
$ 240.00
50 mg
$ 370.00
100 mg
$ 560.00
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