(S)-(+)-N-3-Benzylnirvanol

SKU: orb1741344

Description

(S)-(+)-N-3-Benzylnirvanol is a potent and selective inhibitor of cytochrome P450 2C19 (CYP2C19), exhibiting a Ki of 0.25 µM, while showing weaker activity against CYP2C9 (Ki=82.5 µM). This small molecule is a valuable pharmacological tool for in vitro and in vivo studies investigating drug metabolism, drug-drug interactions, and research related to HIV infection.

Research Area

Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	790676-40-3
MW	294.35
Purity	98.90% (May vary between batches)
Formula	C₁₈H₁₈N₂O₂
SMILES	C(C)[C@@]1(C(=O)N(CC2=CC=CC=C2)C(=O)N1)C3=CC=CC=C3
Target	Others,HIV Protease,Cytochromes P450
Solubility	DMSO:50 mg/mL (169.87 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.79 mM)

Bioactivity

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Target IC50	CYP2C19:0.53 µM\|CYP2C19:< 250 nM(Ki)
In Vitro	(S)-(+)-N-3-Benzylnirvanol is a cytochrome P450 CYP2C19 inhibitor with a ki value of 82.5μM for CYP2C9 and 0.25μM for CYP2C19.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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N-3-Benzylnirvanol, HIVProtease, HIV Protease, HIV, CYP2C19, ZSN 76403, ZSN76403, ZSN-76403

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Compound Identifiers

PubChem CID

40633600 ↗

Key Properties

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No computed properties available.

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