S49076 hydrochloride

SKU: orb1226637

Description

S49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2; only inhibits 6% of kinases on a panel of 442 human wild-type and mutated kinases at 100 nM; inhibits the proliferation of MET- and FGFR2-dependent gastric cancer cells, blocks MET-driven migration of lung carcinoma cells, and inhibits colony formation of hepatocarcinoma cells expressing FGFR1/2 and AXL; causes tumor growth arrest in bevacizumab-resistant tumors in cancer xenograft models.Brain Cancer Phase 2 Clinical.

Images & Validation

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Key Properties

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CAS Number	1265966-31-1
MW	474.96
Purity	>98% (HPLC)
Formula	C₂₂H₂₃ClN₄O₄S
SMILES	C1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O.Cl
Target	TAM Receptor
Solubility	DMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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S 49076 | S-49076

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Gene Symbol

TAM Receptor

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