Salvianolic acid B

SKU: orb1305104

Description

Salvianolic acid B is a water-soluble antioxidant derived from Salvia miltiorrhiza. It exhibits antiplatelet, anticoagulant, and antithrombotic activities, making it a valuable research tool for studying cardiovascular diseases and microcirculatory disorders in both in vitro and in vivo models.

Images & Validation

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Key Properties

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CAS Number	115939-25-8
MW	718.59
Purity	95.00% (May vary between batches)
Formula	C₃₆H₃₀O₁₆
SMILES	OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c2O[C@@H]([C@@H](C(=O)O[C@H](Cc3ccc(O)c(O)c3)C(O)=O)c12)c1ccc(O)c(O)c1
Target	Others
Solubility	DMSO:91 mg/mL (126.64 mM)

Bioactivity

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In Vivo

METHODS: To investigate the effects of peripheral arterial disease (PAD), Salvianolic acid B (15 mg/kg) was intraperitoneally injected once daily for 12 days into a hindlimb ischemia mouse model. RESULTS: The Salvianolic acid B group showed significant improvement in blood perfusion, capillary density, muscle edema and M2 marker gene expression. Salvianolic acid B had a protective effect in PAD and enhanced macrophage polarization through the SIRT1/PI3K/AKT pathway.

In Vitro

METHODS: Human lung cancer cell lines NCI-H2030 and NCI-H1650 were treated with Salvianolic acid B (100-600 µM) for 24-48 h. Cell viability was measured by CCK-8 assay. RESULTS: At 24 h of exposure, the cell viability of NCI-H2030 and NCI-H1650 cells was significantly reduced when the concentration of Salvianolic acid B reached 400 µM. At 48 h exposure, the cell viability was significantly reduced until the concentration reached 300 µM, which was significantly higher than that of the control group. METHODS: Human renal proximal tubule cells HK-2 were treated with TGF-β1 (2.5 ng/mL) and Salvianolic acid B (1-10 µM) for 24 h. Gene expression levels were measured by RT-PCR. RESULTS: TGF-β1 significantly inhibited the expression of E-cadherin mRNA in HK-2 cells, while 1-10 µM Salvianolic acid B prevented the loss of its expression.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Salvianolic acid B, T2727, 121521-90-2

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Compound Identifiers

PubChem CID

6451084 ↗

Key Properties

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No computed properties available.

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