Sanguisorbigenin

SKU: orb1297072

Description

Sanguisorbigenin (Tomentosolic acid) is a natural triterpenoid compound with demonstrated antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) in vitro. Its mechanism and potential for in vivo application make it a candidate for research into novel anti-infective agents.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	6812-98-2
MW	454.69
Purity	99.56%
Formula	C₃₀H₄₆O₃
SMILES	[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])C(C)=C(C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)CC[C@H](O)C2(C)C
Target	Antibacterial
Solubility	10% DMSO+90% Corn Oil:1.67 mg/mL (3.67 mM);DMSO:60 mg/mL (131.96 mM)

Bioactivity

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In Vitro

Treatment of Sanguisorbigenin with sub-MIC concentrations (1.56-6.25 μg/mL) significantly inhibited the expression of blaR1, mecA, and blaZ in MRSA dose-dependently. The gene expression of mecA is remarkably reduced after the treatment of Sanguisorbigenin. The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decreasing PBP2a expression.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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3beta-Hydroxyurs-12,19-dien-28-oic acid, 3b-Hydroxyurs-12,19-dien-28-oic acid, 3β-Hydroxyurs-12,19-dien-28-oic acid, 19-Dehydroursolic acid, Bacterial, antibacterial, MRSA, inhibit, PBP2a, Inhibitor, mecA, Tomentosolic acid, S. aureus, Sanguisorbigenin, Ursa-12,19-dien-28-oic acid

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Compound Identifiers

PubChem CID

101967102 ↗

Key Properties

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No computed properties available.

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