SARS-CoV-2 Mpro-IN-2

SKU: orb1686944

Description

SARS-CoV-2 Mpro-IN-2 is a potent and selective inhibitor of the SARS-CoV-2 main protease (Mpro), exhibiting an IC50 of 0.40 µM. It demonstrates antiviral activity in cellular assays and serves as a valuable research tool for investigating COVID-19 pathogenesis and potential therapeutic strategies.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	2768834-39-3
MW	475.39
Purity	99.97%
Formula	C₂₂H₂₀Cl₂N₄O₂S
SMILES	C(NCC1=CC=CS1)(=O)[C@H]2N(CCN(C(=O)C=3C=CC=NC3)C2)C4=CC(Cl)=C(Cl)C=C4
Target	SARS-CoV

Bioactivity

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Target IC50	Mpro:0.40 μM\|Vero E6:100 μM (CC50)
In Vivo	In male Sprague-Dawley rats, SARS-CoV-2 Mpro-IN-2 (2 mg/kg intravenous injection; 10 mg/kg oral administration; single dose) exhibited favorable pharmacokinetic parameters . Read more...
In Vitro	In Vero E6 cells, SARS-CoV-2 Mpro-IN-2 (0.01-100 μM; 4 hours) exhibited low cytotoxicity, with a CC50 value exceeding 100 μM.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SARSCoV, SARS-CoV-2M pro

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Compound Identifiers

PubChem CID

164946686 ↗

Key Properties

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No computed properties available.

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