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SARS-CoV-2 spike protein (RBD) neutralizing (C-A11) rabbit mAb Antibody
SKU: orb1945971
Description
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| Tested Applications | FA |
|---|---|
| Dilution range | This antibody recognizes the SARS-CoV-2 Spike Protein RBD domain and inhibits the interaction between SARS-CoV-2 RBD and ACE2. Can be paired with other antibody for detection in sandwich ELISA format. |
| Reactivity | Other |
Key Properties
−| Host | Rabbit |
|---|---|
| Clonality | Monoclonal |
| Isotype | Rabbit IgG1k |
| Clone No. | CoV2-CA11 |
| Immunogen | recombinant protein (RBD) |
| Purification | Protein A |
| Conjugation | Unconjugated |
Storage & Handling
−| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
|---|---|
| Form/Appearance | Liquid |
| Buffer/Preservatives | 1X PBS |
| Concentration | 0.5 mg/mL |
| Disclaimer | For research use only |
Alternative Names
−Spike protein S1, Spike protein S2, RBD domain, Binding to ACE-2 receptor, SARS-CoV-2 variants, U.K variant B.1.1.7, South Africa variant B.1.351
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Flow cytometry neutralizing assay: C-A11 displayed dose dependent blocking of spike proteins (wild type and UK variant) to ACE2 expressing cells.
Affinity assessment of SARS-CoV-2 C-A11 IgG to wild type and B.1.1.7 (UK) S1 + S2 trimers. C-A11 possesses very low (pM) KD affinity to both variants.
Flow cytomery neutralizing assay of C-A11 (plotted graphs): ACE2 transfected cells were incubated with biotinylated spike protein (0.5 ug/mL) in the presence or absence of antibody. Binding of spike protein was detected with DyLight488 conjugated StreptAv
Binding of C-A11 to SARS-CoV-2 variants (UK and South Africa): C-A11 shows good cross reactivity to both variants B.1.1.7 (UK) and B.1.351 (S. Africa).
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SARS-CoV-2 spike protein (RBD) neutralizing (C-A11) rabbit mAb Antibody (orb1945971)
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