SB-505124 hydrochloride

SKU: orb1705004

Description

SB-505124 hydrochloride is a potent, selective, and orally active inhibitor of TGF-β type I receptors (ALK4/5/7). It has been shown to inhibit IL-6 production in synovial explants and reduce Th17 differentiation in mice, making it a valuable tool for studying pathways in inflammation, autoimmunity, and cancer research such as colorectal cancer.

Research Area

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

−

Key Properties

−

CAS Number	356559-13-2
MW	371.86
Purity	98.71% (May vary between batches)
Formula	C₂₀H₂₂ClN₃O₂
SMILES	Cl.N=1C(=CC=CC1C)C=2N=C(NC2C=3C=CC=4OCOC4C3)C(C)(C)C
Target	ALK,TGF-beta/Smad
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.38 mM);Methanol:120 mg/mL (322.7 mM);DMSO:40 mg/mL (107.57 mM)

Bioactivity

−

In Vivo

SB-505124 (5 mg/kg; i.p.) alone does not elicit any response in C57Bl6 mice bearing A549 xenografts. However, when combined with a single dose of Carboplatin (60 mg/kg), SB-505124 induces sustained therapeutic effects in five subjects, eliminating the need for ongoing maintenance therapy. This synergy presents a potent treatment strategy without continuous intervention in the specified animal model, highlighting its potential efficacy.

Storage & Handling

−

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

SB 505124 hydrochloride, SB505124 hydrochloride, SB-505124 Hydrochloride, ALK4, ALK5, ALK7

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

16079009 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols