SB2960

SB2960 is a binding agent for receptor of activated C kinase 1 (RACK1), with a KD value of 5.65 μM for human proteins. It facilitates the formation of stress granules (SG) and exhibits potent antiviral activity against various viral species. By regulating the host's antiviral immune response, SB2960 inhibits viral replication with minimal cytotoxicity. Additionally, it enhances the thermal stability of RACK1 and decreases the level of the SARS-CoV-2 N protein. SB2960 boosts the expression of type I interferon (IFN-β) while suppressing the expression of RIG-I, ISG56, and RANTES, making it useful for research related to viral infections.