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SC-236

SKU: orb1298875

Description

SC-236 is a potent and selective COX-2 inhibitor, demonstrating high oral activity. It exhibits significant selectivity with an IC50 of 0.005 μM for COX-2 versus 17.8 μM for COX-1. This compound is widely used in research models of inflammation, pain, and cancer, both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Neuroscience

Images & Validation

Key Properties

CAS Number170569-86-5
MW401.79
Purity99.74% (May vary between batches)
FormulaC16H11ClF3N3O2S
SMILESNS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(Cl)cc1)C(F)(F)F
TargetPPAR,COX,Apoptosis
SolubilityDMSO:22.5 mg/mL (56 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.98 mM)

Bioactivity

Target IC50
COX-1:17.8 μM|COX-2:0.005 μM
In Vivo
SC-236 protects against cartilage damage in addition to reducing inflammation and pain for those with osteoarthritis

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SC 236, Sc 236, SC236, SC-236, TNF-α, Peroxisome proliferator-activated receptors, PPAR, fibrogenesis, gastric, fibrosis, Inhibitor, neuroprotection, inhibit, ischemia, Liver, allodynia, cancer, Apoptosis, COX, COX-2, Cyclooxygenase
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

SC-236 (orb1298875)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 ml x 10 mM (in DMSO)
$ 90.00
5 mg
$ 90.00
10 mg
$ 110.00
25 mg
$ 170.00
50 mg
$ 270.00
100 mg
$ 370.00
200 mg
$ 520.00
DispatchUsually dispatched within 3-5 working days
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