SC144

SKU: orb1300980

Description

SC144 is a potent, orally bioavailable small molecule that selectively inhibits gp130 signaling. It has demonstrated efficacy in reducing tumor growth in vivo and is widely used in cancer research, particularly for studying IL-6/JAK/STAT3 pathways in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	895158-95-9
MW	322.3
Purity	99.85% (May vary between batches)
Formula	C₁₆H₁₁FN₆O
SMILES	Cl.Fc1ccc2c(c1)nc(NNC(=O)c1cnccn1)c1cccn21
Target	Apoptosis,Interleukin
Solubility	Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:15 mg/mL (46.54 mM)

Bioactivity

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Target IC50	Gp130:< 1 μM (Cell assay)
In Vivo	SC144 significantly inhibits tumor growth in a mouse xenograft model of human ovarian cancer via i.p. or p.o. administration. After SC144 treatment for two months, gp130, Bcl-2, Bcl-XL, MMP-7 and Ape1/Ref-1 protein levels are substantially decreased in the tumor site in the treatment group compared with the control group. In an MDA-MB-435 mouse xenograft model, co-administration of SC144 and paclitaxel delays tumor growth in an SC144 dose-dependent manner. Evaluation of the pharmacokinetics of SC144 reveals that intraperitoneal administration of SC144 shows a two-compartmental pharmacokinetics elimination profile that is not observed in the oral dosing. Read more...
In Vitro	SC144 exhibits potent cytotoxicity against a panel of drug-sensitive and drug-resistant cancer cell lines. SC144 shows synergism with both 5-fluorouracil and oxaliplatin when co-treated in colorectal cancer HT29 cells. Pretreatment with SC144 in oxaliplatin-resistant HTOXAR3 cells is more effective than oxaliplatin pretreatment. In addition, the combination of SC144 and paclitaxel exhibited synergism in MDA-MB-435 cells with a schedule-dependent block in cell cycle. SC144 treatment in vitro induces gp130 phosphorylation and deglycosylation, resulting in the downregulation of surface-bound gp130 and the abrogation of gp130-associated Stat3 activation. In addition, SC144 selectively inhibits the downstream signaling activation induced by gp130 substrates, including IL-6 and LIF. Protein expression regulated by the gp130/Stat3 axis in OVCAR-8 cells is also down-regulated after SC144 treatment, including Bcl-2, Bcl-XL, survivin, cyclin D1, MMP-7, gp130 and Ape1/Rel-1. Read more...
Cell Research	MTT assay (Only for Reference)

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, nuclear, oral, ovarian, Inhibitor, Interleukin Related, Interleukin, gp130, cancer, arrest, anti-angiogenesis, Apoptosis, cell-cycle, phosphorylation, SC144, SC-144, SC 144, translocation

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Compound Identifiers

PubChem CID

66921431 ↗

Key Properties

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No computed properties available.

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SC144 (orb1300980)

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CAS Number:	917497-70-2
MW:	358.76
Formula:	C₁₆H₁₂ClFN₆O

Purity:	>98% (HPLC)
CAS Number:	895158-95-9
MW:	322.3
Formula:	C₁₆H₁₁FN₆O

SC144

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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SC144 (orb1300980)

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