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Sciadopitysin

SKU: orb1222121

Description

Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in osteoblastic MC3T3-E1 cells, it may reduce or prevent osteoblasts degeneration.Sciadopitysin can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.

Images & Validation

Key Properties

CAS Number521-34-6
MW580.54
Purity>98% (HPLC)
FormulaC33H24O10
SMILESOc1cc(OC)cc2OC(=CC(=O)c12)c6cc(c5c(O)cc(O)c3c5OC(=CC3=O)c4ccc(OC)cc4)c(OC)cc6
TargetOpioid Receptor
SolubilityIn Vitro: DMSO : 20 mg/mL (34.45 mM)

Bioactivity

In Vivo
Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old).
In Vitro
Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Sciadopitysin | NSC 45108 | NSC-45108 | NSC45108

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Sciadopitysin (orb1222121)

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Available Sizes

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5 mg
$ 160.00
10 mg
$ 240.00
25 mg
$ 440.00
50 mg
$ 640.00
100 mg
$ 910.00
500 mg
$ 1,840.00