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Sciadopitysin

SKU: orb1301256

Description

Sciadopitysin is a research compound studied for its potential to protect against diabetic bone disease by enhancing mitochondrial biogenesis. It has demonstrated protective effects in osteoblast cell models and shown activity against amyloid-beta toxicity in neuronal cultures, indicating relevance for bone and neurodegenerative research.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number521-34-6
MW580.54
Purity99.08%
FormulaC33H24O10
SMILESCOc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3OC)-c3cc(=O)c4c(O)cc(OC)cc4o3)c2o1
TargetNF-κB,TNF
SolubilityDMSO:135 mg/mL (232.54 mM)

Bioactivity

Cell Research
Pretreatment of MC3T3-E1 cells with Sciadopitysin prevented the MG-induced cell death and protein adducts formation. Sciadopitysin restored the MG-induced change in glyoxalase activity almost to the control level and increased glutathione levels. In addition, Sciadopitysin decreased MG-induced formation of intracellular reactive oxygen species (ROS), mitochondrial superoxide, and cardiolipin peroxidation. These findings suggest that Sciadopitysin provides a protective action against MG-induced glycation by increasing MG detoxification system and by reducing oxidative stress. Pretreatment with Sciadopitysin prior to MG exposure reduced MG-induced mitochondrial dysfunction by preventing mitochondrial membrane potential (MMP) dissipation and adenosine triphosphate (ATP) loss.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

osteoclastogenesis, Sciadopitysin, TNF-α, biloba, Biflavonoids, bone, NF-κB, NF-kB, NFkB, NFκB, Nuclear factor-kappaB, Nuclear factor-κB, loss, inhibit, ginkgo, Inhibitor

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Sciadopitysin (orb1301256)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 210.00
25 mg
$ 360.00
50 mg
$ 520.00
100 mg
$ 730.00
500 mg
$ 1,460.00
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