Scopoletin

SKU: orb1304772

Description

Scopoletin, also known as Esculetin 6-methyl ether, is a natural coumarin isolated from Scopolia carniolica. It functions as an acetylcholinesterase (AChE) inhibitor and is utilized in neurological research, including in vitro enzyme assays and studies of plant physiology.

Research Area

Cell Biology, Neuroscience

Images & Validation

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Key Properties

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CAS Number	92-61-5
MW	192.168
Purity	99.88% (May vary between batches)
Formula	C₁₀H₈O₄
SMILES	COC1=C(O)C=C2OC(=O)C=CC2=C1
Target	Apoptosis,AChR,Cholinesterase (ChE)
Solubility	DMSO:62.5 mg/mL (325.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.41 mM)

Bioactivity

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In Vivo

Female BALB/c mice were treated with Mogroside V (2.5, 5 and 10 mg/kg) for 1 h prior to intranasal injection of LPS (10 μg in 50 μl). After 12 h, airway inflammation in the ALI model was determined by the wet/dry weight (W/D) ratio, myeloperoxidase (MPO) activity of lung tissue, leukocyte recruitment and cytokine levels in the bronchoalveolar lavage fluid (BALF). Additionally, lung tissue was examined by histology and western blotting to investigate the changes in pathology and the signalling in the presence and absence of Mogroside V. Mogroside V at 5 and 10 mg/kg inhibited airway inflammation induced by LPS as measured by the decrease in the histological changes (44 and 67.3% reduction in lung injury score, respectively), a 28.9 and 55.3% reduction in lung MPO activity, and inflammatory cell counts, interleukin-1β (IL-1β, 382 and 280 pg/ml, respectively), IL-6 (378 and 232 pg/ml, respectively) and tumor necrosis factor-α (TNF-α, 12.5 and 7.8 ng/ml, respectively) levels in the BALF. Additionally, Mogroside V treatment reduced the activation of cyclooxygenase 2 (COX-2), inducible NO synthase (iNOS), and the nuclear factor (NF)-κB.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Scopoletin, Gelseminic acid, Esculetin 6-methyl ether, Inhibitor, inhibit, mAChR, Apoptosis, 6-Methylesculetin, AChE, Chrysatropic acid, Cholinesterase (ChE)

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Compound Identifiers

PubChem CID

5280460 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Purity:	>90%
Source:	Microorganism

Purity:	99.30% (May vary between batches)
CAS Number:	56795-51-8
MW:	234.2
Formula:	C₁₂H₁₀O₅

CAS Number:	1660110-65-5
MW:	371.77
Formula:	C₁₉H₁₄ClNO₅

CAS Number:	487-27-4
MW:	155.19
Formula:	C₈H₁₃NO₂

CAS Number:	41653-72-9
MW:	246.3
Formula:	C₁₅H₁₈O₃

Scopoletin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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