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Seganserin

SKU: orb1745180

Description

Seganserin is a non-selective 5-HT2 receptor antagonist that counteracts the effects of fluoxetine and quipazine. It is used in neuroscience research to study serotonergic pathways, particularly in animal models investigating feeding behavior, depression, and pain modulation.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number87729-89-3
MW471.54
Purity99.71%
FormulaC29H27F2N3O
SMILESC(=C1CCN(CCC=2C(=O)N3C(=NC2C)C=CC=C3)CC1)(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5
Target5-HT Receptor
SolubilityDMSO:55 mg/mL (116.64 mM)

Bioactivity

In Vivo
Seganserin (2 mg/kg, i.p.; mice), a 5-HT(2) receptor antagonist pretreatment significantly reversed fluoxetine and quipazine-induced antidepressant and analgesic effects. Seganserin (2 mg/kg, i.p.; mice), significantly reversed the suppressive effect of fluoxetine and quipazine on progesterone-induced hyperphagia, depression, and algesia in the hot-plate test.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

5HTReceptor, 5-HT, 5HT Receptor
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Key Properties

No computed properties available.

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Protocol Information

Seganserin (orb1745180)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 240.00
5 mg
$ 470.00
10 mg
$ 680.00
25 mg
$ 1,030.00
50 mg
$ 1,400.00
100 mg
$ 1,870.00
500 mg
$ 3,720.00
DispatchUsually dispatched within 3-5 working days
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