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Setrobuvir

SKU: orb1699319

Description

Setrobuvir (ANA-598) is a potent, orally bioavailable non-nucleoside inhibitor of the HCV NS5B polymerase, effective in the low nanomolar range. It also demonstrates binding affinity and inhibitory activity against the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), supporting its investigation in antiviral research for both hepatitis C and COVID-19.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1071517-39-9
MW560.62
Purity>99.99% (May vary between batches)
FormulaC25H25FN4O6S2
SMILESC(N1[C@@]2([C@@]([C@@]3(C[C@]2(CC3)[H])[H])(C(O)=C(C1=O)C=4NC=5C(S(=O)(=O)N4)=CC(NS(C)(=O)=O)=CC5)[H])[H])C6=CC=C(F)C=C6
TargetSARS-CoV,HCV Protease,DNA/RNA Synthesis
SolubilityDMSO:252.5 mg/mL (450.39 mM)

Bioactivity

Target IC50
HCV NS5B 1a:52 nM (EC50)|RNA synthesis and primer extension:4~5 nM|HCV NS5B 1b:3 nM (EC50)
In Vivo
Setrobuvir (200, 400, and 800 mg) BID were -2.1, -2.2, and -2.9 log10 IU/mL, respectively (vs ≤0.1 log10 IU/mL with placebo).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

HCVProtease, HCV Protease, HCV NS5B polymerase, DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, ANA 598, ANA598, ANA-598, Setrobuvir, SARS-CoV-2, SARSCoV, RO 5466731, RO5466731, RO-5466731, RNASynthesis, RNA Synthesis, RG 7790, RG7790, RG-7790
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

Setrobuvir (orb1699319)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 280.00
5 mg
$ 640.00
1 ml x 10 mM (in DMSO)
$ 820.00
10 mg
$ 900.00
25 mg
$ 1,320.00
50 mg
$ 1,790.00
100 mg
$ 2,400.00
500 mg
$ 4,770.00
DispatchUsually dispatched within 3-5 working days
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