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Shanzhiside methyl ester

SKU: orb1221921

Description

Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p38 MAPK signaling.

Images & Validation

Key Properties

CAS Number64421-28-9
MW406.38
Purity>98% (HPLC)
FormulaC17H26O11
SMILES[C@@H]1([C@H]2[C@@H](C(=CO1)C(=O)OC)[C@@H](C[C@]2(C)O)O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO
TargetDNA/RNA Synthesis
SolubilityIn Vitro: DMSO : 100 mg/mL (246.08 mM)

Bioactivity

In Vivo
Shanzhiside methyl ester exerts dose-dependent and long-lasting (>4 h) anti-allodynic effects in spinal nerve injury-induced neuropathic rats, with a maximal inhibition of 49% and a projected ED50 of 40.4 μg.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Shanzhiside methyl ester (orb1221921)

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