Cart summary

You have no items in your shopping cart.

(±)-Shikonin

SKU: orb1304876

Description

(Rac)-Shikonin

Images & Validation

Key Properties

CAS Number54952-43-1
MW288.3
Purity99.73%
FormulaC16H16O5
SMILESO=C1C=2C(C(=O)C=C1C(CC=C(C)C)O)=C(O)C=CC2O
TargetOthers
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:10 mM

Bioactivity

In Vitro
At nanomolar concentrations, shikonin inhibits monocyte chemotaxis and calcium flux in response to a variety of CC chemokines (CCL2 [monocyte chemoattractant protein 1], CCL3 [macrophage inflammatory protein 1α], and CCL5 [regulated upon activation, normal T-cell expressed and secreted protein]), the CXC chemokine (CXCL12 [stromal cell-derived factor 1α]), and classic chemoattractants (formylmethionyl-leucine-phenylalanine and complement fraction C5a). Shikonin down-regulates surface expression of CCR5, a primary HIV-1 coreceptor, on macrophages. The anti-HIV and anti-inflammatory activities of shikonin may be related to its interference with chemokine receptor expression and function. Shikonin inhibits enterocyte calcium-activated chloride channels, the inhibitory effect is partially through inhibition of basolateral K+ channel activity.
Cell Research
Freshly isolated human monocytes are plated in a 96-microwell plate (Costar) at 105 cells per well with shikonin at a final concentration of 10, 1, 0.1, 0.01 μM. The numbers of viable cells, as detected by MTS test and the trypan blue exclusion assay, were measured 12 and 24 h after incubation at 37°C in humidified air with 5% CO2. (Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Anchusa acid, Anchusin, (±)-Shikonin, (Rac)Shikonin, (Rac)-Shikonin, (Rac) Shikonin, Alkanet extract, Inhibitor, inhibit, Shikalkin, Shikonin

Similar Products

  • (+)-Shikonin [orb1309685]

    99.11%

    517-89-5

    288.30

    C16H16O5

    100 mg, 500 mg, 1 ml x 10 mM (in DMSO), 5 mg, 10 mg, 25 mg, 50 mg, 200 mg
  • Shikonin [orb702125]

    98.0%(HPLC e.e.40%)

    517-89-5

    20 mg
  • PKM2/PDK1-IN-1 [orb1982596]

    697.92

    C36H43NO7S3

    50 mg, 5 mg
  • Deoxyshikonofuran [orb2942975]

    104056-81-7

    258.312

    C16H18O3

    10 mg, 50 mg
  • (2-Methylbutyryl)shikonin [orb1684063]

    52387-15-2

    372.41

    C21H24O6

    100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

(±)-Shikonin (orb1304876)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
$ 80.00
10 mg
$ 80.00
25 mg
$ 90.00
50 mg
$ 110.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry