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SI-W052

SKU: orb3027924

Description

SI-W052 is an orally active, brain-penetrant, and selective small molecule inhibitor that targets mTOR and TEX264. It activates autophagy by inhibiting mTOR phosphorylation, enhances TEX264 expression to promote endoplasmic reticulum renewal, and suppresses the release of LPS-induced inflammatory factors (TNF-α, IL-6). SI-W052 shows potential for research into neuroinflammation associated with Alzheimer's disease (AD).

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number2572552-60-2
MW434.89
FormulaC20H19ClN2O5S
SMILESO=C(O)C1=CC(=C(Cl)C=C1NCC=2OC=CC2)S(=O)(=O)N(C)CC=3C=CC=CC3
TargetInterleukin,mTOR,Autophagy

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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SI-W052 (orb3027924)

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