Siegeskaurolic acid

SKU: orb1681684

Description

Siegeskaurolic acid is a bioactive small molecule that demonstrates anti-inflammatory and antinociceptive properties. Its mechanism involves the suppression of NF-κB signaling, leading to reduced iNOS and COX-2 expression in macrophages. This activity supports its use in research models for inflammation and pain, both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	52645-97-3
MW	320.47
Purity	98.00% (May vary between batches)
Formula	C₂₀H₃₂O₃
SMILES	C[C@]12[C@]3([C@]4(C[C@@](CC3)([C@H](CO)C4)[H])CC[C@@]1([C@@](C(O)=O)(C)CCC2)[H])[H]
Target	Prostaglandin Receptor,COX,NO Synthase,TNF,NF-κB,NOS

Bioactivity

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In Vivo	Pretreatment with Siegeskaurolic acid (20 or 30 mg/kg/day, p.o.) exhibited anti-inflammatory and antinociceptive effects in acetic acid-induced mouse models. Read more...
In Vitro	Siegeskaurolic acid inhibits iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB inactivation.

Storage & Handling

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Storage	store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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TNF-α, Siegeskaurolic acid, PGE, Prostaglandin Receptor, ProstaglandinReceptor, COX, NOSynthase, NOS, NF-κB, NFkB, NF-kB, NFκB, NO, NO Synthase, p65

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Compound Identifiers

PubChem CID

44575990 ↗

Key Properties

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No computed properties available.

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