Siltuximab Antibody

SKU: orb1980466

Description

Siltuximab (CNTO-328) is a human-mouse chimeric monoclonal antibody that specifically targets interleukin-6 (IL-6). It is utilized in research for conditions like multicentric Castleman disease (MCD) and has been investigated in preclinical and clinical studies for its role in modulating cytokine storms, including in COVID-19 research.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	541502-14-1
MW	144.98 kDa
Purity	100% (SEC-HPLC)
Target	Interleukin,IL Receptor

Bioactivity

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In Vivo	In xenograft mouse models, Siltuximab, when administered through intraperitoneal injection at a dosage of 10 mg/kg three times per week, inhibits the growth of lung cancer cells. Furthermore, in a xenograft model, the growth of MCF-7 tumors is inhibited by Siltuximab with intraperitoneal injections at a dose of 20 mg/kg twice per week for 6 weeks. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ILReceptor, IL-6, IL Receptor, CNTO-328

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Gene Symbol

Interleukin,IL Receptor

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