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Silychristin

SKU: orb1222352

Description

Silychristin is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.

Images & Validation

Key Properties

CAS Number33889-69-9
MW482.44
Purity>98% (HPLC)
FormulaC25H22O10
SMILESCOc1cc(ccc1O)[C@@H]1Oc2c(cc(cc2O)[C@H]2Oc3cc(O)cc(O)c3C(=O)[C@@H]2O)[C@H]1CO
Target5-Lipoxygenase
SolubilityIn Vitro: DMSO : 100 mg/mL (207.28 mM)

Bioactivity

In Vitro
Silychristin exhibits a strong inhibition of MCT8-mediated T3 uptake with an IC50 of 110 nM in MCT8 overexpressing MDCK1-cells. Silychristin causes no cytotoxic for fibroblasts. Silychristin (6.5-75 μM; 24 hours) diminishes UVA toxicity and reduces ROS generation, and the protective effect is dose-dependent. Silychristin (12.5 μM, 25 μM) reduces the metalloproteinase-1 (MMP-1) level in cells. Cell Viability Assay Cell line: NHDF. Concentration: 6.5 μM, 12.5 μM, 25 μM, 50 μM, 75 μM Incubation time: 24 hours. Result: Diminished UVA toxicity and reduced ROS generation in dose-dependent. Cell Viability Assay Cell line: NHDF. Concentration: 12.5 μM, 25 μM Incubation time: Result: Reduced the metalloproteinase-1 (MMP-1) level in cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Silychristin (orb1222352)

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Available Sizes

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200 mg
500 mg
5 mg
$ 110.00
10 mg
$ 150.00
25 mg
$ 230.00
50 mg
$ 330.00
100 mg
$ 470.00