Simvastatin acid ammonium

SKU: orb1706632

Description

Simvastatin acid ammonium (Tenivastatin ammonium) is a competitive HMG-CoA reductase inhibitor that blocks cholesterol biosynthesis. It is widely used in biochemical research to study lipid metabolism and evaluate hypolipidemic effects in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	139893-43-9
MW	453.61
Purity	98.30% (May vary between batches)
Formula	C₂₅H₄₃NO₆
SMILES	CCC(C)(C)C(O[C@@H]1[C@@]2([H])C(C=C[C@@H]([C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C)=C[C@@H](C1)C)=O.[NH4+]
Target	HMG-CoA Reductase,ROS,Reactive Oxygen Species
Solubility	DMSO:4 mg/mL (8.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.2 mM)

Bioactivity

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In Vitro	Simvastatin acid ammonium (0.1-20 μM, treated for 24 h) significantly inhibited ROS production in indolephenol sulfate-treated hCM cells, with reductions ranging from 8.9% to 43%. In addition, 0.1-20 μM Simvastatin acid ammonium, treated for 24 hours, also affected the expression level of OATP3A1 protein in hCM and OATP3A1-expressing HEK293 cells. Read more...

Storage & Handling

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Storage	keep away from direct sunlight,keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Tenivastatin ammonium, Simvastatin acid ammonium, Human Endogenous Metabolite

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Compound Identifiers

PubChem CID

10961424 ↗

Key Properties

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No computed properties available.

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