Simvastatin Hydroxy Acid Sodium Salt

SKU: orb3054059

Description

Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor.

Images & Validation

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Key Properties

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CAS Number	101314-97-0
MW	458.56
Purity	>98% (HPLC)
Formula	C₂₅H₃₉NaO₆

Bioactivity

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In Vitro

Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells. Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells. Western blot analysis. Cell line: hCM and HEK293 (transfected with OATP3A1). Concentration: 0.1, 1, 10 and 20 μM Incubation time: 24 h. Result: Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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