Sinapine thiocyanate

SKU: orb1221822

Description

Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-oxidants and acetylcholinesterase inhibitors, that can be used for the treatment of Alzheimer’s disease (AD).

Images & Validation

−

Key Properties

−

CAS Number	7431-77-8
MW	368.45
Purity	>98% (HPLC)
Formula	C₁₆H₂₄NO₅·CNS
SMILES	C[N+](C)(C)CCOC(=O)/C=C/c1cc(c(cc1OC)O)OC.C(#N)[S-]
Target	AChR
Solubility	DMSO : ≥ 125 mg/mL; 339.26 mM

Bioactivity

−

In Vivo

Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota.

In Vitro

Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes. Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity. Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease. Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2.

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol

AChR

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols