Cart summary

You have no items in your shopping cart.

SM-7368

SKU: orb1940431

Description

The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.

Images & Validation

Key Properties

CAS Number380623-76-7
MW328.69
Purity>98% (HPLC)
FormulaC10H5ClN4O5S
SMILES[O-][N+](c1cnc(NC(c(cc2)cc(Cl)c2[N+]([O-])=O)=O)s1)=O
TargetNF-κB
SolubilityIn Vitro: DMSO : 83.33 mg/mL (253.52 mM)

Bioactivity

In Vitro
SM-7368 (5 μM) targets downstream of MAPK p38 activation in the human colon derived crypt like HT-29 and Caco-2 epithelial cell lines. SM-7368 inhibits TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and shows maximal activity at 10 μM. SM-7368 inhibits TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line. SM-7368 (10-25 μM) greatly inhibits TNF-α (20 ng/mL)-induced MMP-9 upregulation. 10 μM of SM-7368 almost completely abrogates this upregulation. Western blot analysis. Cell line: HT1080 human fibrosarcoma cells. Concentration: 0, 1, 5, 10, 15, 20, and 25 μM. Incubation time: 24 hours. Result: Greatly inhibited TNF-α (20 ng/mL)-induced MMP-9 upregulation in a concentration-dependent manner.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NF-κB Activation Inhibitor III | SM 7368

Similar Products

  • SM-7368 [orb1306091]

    99.64%

    380623-76-7

    328.69

    C10H5ClN4O5S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 1 ml x 10 mM (in DMSO)
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

SM-7368 (orb1940431)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 120.00
10 mg
$ 180.00
25 mg
$ 320.00
50 mg
$ 480.00
100 mg
$ 690.00
500 mg
$ 1,420.00