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SMCC-DM1

SKU: orb1307740

Description

SMCC-DM1 is a chemical linker-payload conjugate designed for constructing antibody-drug conjugates (ADCs). The cytotoxic agent DM1 inhibits microtubule polymerization, while the SMCC linker enables stable attachment to antibodies. This reagent is widely used in preclinical research for developing targeted cancer therapies, with applications in both in vitro cytotoxicity assays and in vivo xenograft models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1228105-51-8
MW1072.61
Purity99.25% (May vary between batches)
FormulaC51H66ClN5O16S
SMILESCO[C@@H]1\C=C/C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(=O)CCSC2CC(=O)N(CC3CCC(CC3)C(=O)ON3C(=O)CCC3=O)C2=O)[C@]2(C)O[C@H]2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2
TargetDrug-Linker Conjugates for ADC,PROTAC Linker
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.86 mM);DMSO:90 mg/mL (83.91 mM)

Bioactivity

In Vitro
METHODS: The antiproliferative effects of SMCC-DM1, LDs 17 and LDs 18) on two cell lines, HCC-1954 (her2 positive) and MDA-MB-468 (her2 negative), were evaluated using Promega cell titer-glo fluorescence cell viability assay. RESULTS SMCC-DM1 inhibited the proliferation of HCC1954 and MDA-MB-468 cells with IC50 of 17.2 and 49.9 nM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

DM1-SMCC, DrugLinkerConjugatesforADC, DrugLinker Conjugates for ADC, Drug-Linker Conjugates for ADC, inhibit, Inhibitor, Maytansinoids, SMCC DM1, SMCCDM1, SMCC-DM1, SMCC-DM-1

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

SMCC-DM1 (orb1307740)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 140.00
5 mg
$ 190.00
10 mg
$ 320.00
25 mg
$ 510.00
50 mg
$ 730.00
100 mg
$ 1,020.00
200 mg
$ 1,360.00
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