Cart summary

You have no items in your shopping cart.

Smilagenin

SKU: orb1689945

Description

Smilagenin is a natural anthocyanin glycoside that acts as an acetylcholinesterase inhibitor (IC50 = 43.29 mg/L). It exhibits neuroprotective properties by enhancing CREB phosphorylation, increasing GDNF and BDNF expression, and counteracting Aβ-induced neurodegeneration in research models, supporting its study in neuroscience and neuropharmacology.

Research Area

Epigenetics & Chromatin, Neuroscience, Signal Transduction

Images & Validation

Key Properties

CAS Number126-18-1
MW416.64
Purity98.00% (May vary between batches)
FormulaC27H44O3
SMILESC[C@@H]1[C@]2(O[C@@]3([C@]1([C@]4(C)[C@@](C3)([C@]5([C@](CC4)([C@]6(C)[C@](CC5)(C[C@@H](O)CC6)[H])[H])[H])[H])[H])[H])CC[C@@H](C)CO2
TargetCholinesterase (ChE),Epigenetic Reader Domain,GDNF
SolubilityDMSO:< 1 mg/mL (insoluble);Ethanol:≥ 8 mg/mL

Bioactivity

In Vivo
Smilagenin (10 or 26 mg/kg, intragastric administration, once daily for 60 days) has a protective effect against damage to dopaminergic neurons in a chronic MPTP/Probenecid-induced mouse model .
In Vitro
In MPP+-treated SH-SY5Y cells, Smilagenin (10 μM, 24 hours) increased the mRNA levels of GDNF and BDNF by promoting CREB phosphorylation . Smilagenin (10 μM, 24 hours) enhanced the survival rate of SH-SY5Y cells .

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PYM 50028, PYM50028, PYM-50028, Cogane, AI344895, AI3-44895, Smilagenin

Similar Products

  • SMILAGENIN ACETATE [orb1302421]

    99.81%

    4947-75-5

    458.67

    C29H46O4

    50 mg, 100 mg, 25 mg, 2 mg, 200 mg, 10 mg, 5 mg
  • SMILAGENIN ACETATE [orb1221296]

    >98% (HPLC)

    4947-75-5

    458.67

    C29H46O4

    10 mg, 25 mg, 1 g, 500 mg, 200 mg, 100 mg, 5 mg, 50 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Smilagenin (orb1689945)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 70.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 140.00
25 mg
$ 220.00
50 mg
$ 300.00
100 mg
$ 420.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry