SN50

SKU: orb1708506

Description

SN50 is a cell-permeable peptide inhibitor that blocks NF-κB nuclear translocation by mimicking the p50 subunit's nuclear localization sequence. It has demonstrated protective effects in rat models of ventilator-induced lung injury, suppresses pro-inflammatory mediators like IL-1β and TNF-α, and promotes M2 microglial polarization in research applications.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

−

Key Properties

−

CAS Number	213546-53-3
MW	2781.5
Purity	99.91% (May vary between batches)
Formula	C₁₂₉H₂₃₀N₃₆O₂₉S
SMILES	C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)N)=O)C)=O)C(C)C)=O)C)=O)CC(C)C)=O)CC(C)C)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(O)=O)CCC3)CCSC)=O)CC(C)C)=O)CCCCN)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)C(C)C)=O)CCC2)C)=O)CC(C)C)=O)CC(C)C)=O)C)=O)CC(C)C)=O)CC(C)C)=O)C(C)C)=O)C)=O)CCC1
Target	NF-κB,Glutathione Peroxidase,MAPK,IL Receptor
Solubility	H2O:40 mg/mL (14.38 mM);DMSO:80 mg/mL (28.76 mM)

Bioactivity

−

In Vivo

SN50 enhances motor function recovery from the first to the fourth day and shows a significant reduction in visuospatial learning latencies on the seventh and eighth days post-TBI, compared to the control group. Furthermore, SN50 pretreatment significantly decreases NF-κB p65 and TNF-a protein levels between 6 to 48 hours post-TBI.

In Vitro

Compared with vehicle-treated groups,pretreatment with SN50 results in a significant reduction in amount of PI-positive cells at 12, 24, and 48 h time-point post TBI . Local SN50 inhibits the activation of nuclear factor-κB in local cells and reduces the occurrence of epithelial defects/ulcers during corneal healing. Myofibroblast generation, macrophage invasion, activity of matrix metalloproteinases, basement membrane destruction, and expression of cytokines are all decreased in treated corneas compared with controls. Treating the human gastric cancer cells SGC7901 with SN50 could significantly enhance the effects of LY294002 on inducing cell death after 24 h. SN50 can inhibit translocation of NF-kB and production of inflammatory cytokines that are implicated in lipopolysaccharide (LPS)-induced lung injury.

Storage & Handling

−

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

NF-κB, NFκB, NFkB, NF-kB, SN50, SN-50, SN 50

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

16209942 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

SN50 (orb1708506)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

SN50

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

SN50 acetate (213546-53-3 free base) [orb1309081]

SN52 [orb1691990]

SN50 TFA [orb1692264]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

SN50 (orb1708506)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors