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SNG-1153

SKU: orb1226261

Description

A derivate of icaritin that inhibits the growth of lung CSCs; inhibits the tumorsphere formation and decreases CD133-positive (lung CSC marker) cancer cells, attenuates tumor formation in NOD/SCID mice; induces β-catenin phosphorylation and down-regulated β-catenin; targets abnormal ERα36 activity, inhibits cell growth and induces apoptosis of BCR-ABL+ leukemic cells, particularly BCR-ABL-T315I mutant cells; effectively eliminates infiltrated BCR-ABL+ blast cells and enhances survival of mice combined with dasatinib.Breast Cancer Preclinical.

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Key Properties

CAS Number1446712-19-1
MW406.3519
Purity>98% (HPLC)
FormulaC21H17F3O5
SMILESO=C1C(O)=C(C2=CC=C(C(F)(F)F)C=C2)OC3=C1C(O)=CC(O)=C3C/C=C(C)\C
TargetEstrogen Receptor/ERR
SolubilityDMSO: ≥ 32 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SNG 1153 | SNG1153

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SNG-1153 (orb1226261)

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Available Sizes

Select a size below

200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 130.00
10 mg
$ 180.00
25 mg
$ 250.00
50 mg
$ 350.00
100 mg
$ 490.00