Phenylbutyrate Na

SKU: orb1308290

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Description

Sodium 4-phenylbutyrate

Research Area

Cell Biology, Epigenetics & Chromatin, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1716-12-7
MW	186.2
Purity	>98%
Formula	C₁₀H₁₁O₂ • Na
SMILES	[Na+].[O-]C(=O)CCCc1ccccc1
Target	Protein deacetylase
Solubility	Soluble in DMSO (up to 4 mg/ml) or in Water (up to 25 mg/ml).

Bioactivity

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In Vivo	In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity. Read more...
In Vitro	In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels. Read more...

Storage & Handling

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Storage	RT
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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4-PB; PBNa

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Compound Identifiers

PubChem CID

5258 ↗

Key Properties

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No computed properties available.

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