Sotrovimab Antibody

SKU: orb1980598

Description

Sotrovimab (VIR-7831) is a monoclonal antibody for researching SARS-CoV-2. It exhibits antiviral activity through neutralization and antibody-dependent cytotoxicity, making it applicable for in vitro neutralization assays and in vivo therapeutic studies against variants like BQ.1.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	2423014-07-5
MW	146.51 kDa
Purity	98.7% (SDS-PAGE); 98.5% (SEC-HPLC)
Target	SARS-CoV

Bioactivity

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Target IC50	SARS-CoV-2 Kappa:118.64 ng/mL\|SARS-CoV-2 Delta:51.3 ng/mL\|SARS-CoV-2 Beta:71.9 ng/mL\|SARS-CoV-2 Gamma:73.11 ng/mL\|SARS-CoV-2 Alpha:187.2 ng/mL
In Vivo	Sotrovimab was able to provide protective exposure to susceptible variants in the lungs of female crab-eating monkeys for up to 28 days after a single dose of 5 mg/kg (10 mL) was administered via intravenous catheter. Read more...
In Vitro	Sotrovimab neutralizes SARS-CoV-2 and SARS-CoV but does not directly block viral receptor binding. Sotrovimab injected into the culture medium for 200 seconds at a concentration of 100 μg/mL (flow rate of 30 μL/min) was effective in binding to the surface-expressed SARS-CoV-2 S protein.Sotrovimab treated for 30 minutes at concentrations ranging from 0.3 ng/mL to 20 mg/mL exhibited in vitro neutralization of SARS-CoV-2 pseudotyped virus, and in vitro neutralization of Alpha, Beta, Gamma, and SARS-CoV. Sotrovimab exhibited in vitro neutralization of SARS-CoV-2 pseudotyped virus at concentrations ranging from 0.3 ng/mL to 20 mg/mL for 30 min, with IC50 values of 187.2 ng/mL, 71.9 ng/mL, 73.11 ng/mL, 51.3 ng/mL, and 118.64 ng/mL for the Alpha, Beta, Gamma, Delta, and Kappa variant viruses, respectively. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SARSCoV, SARS-CoV, VIR 7831, VIR7831, GSK4182136, GSK-4182136

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Quick Database Links

Gene Symbol

SARS-CoV

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