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Description

This peptide, derived from the SARS-CoV Spike protein (residues 668-679), potently inhibits the S protein-ACE2 interaction with an IC50 of 1.88 nM and blocks viral entry into Vero E6 cells in vitro. It shares 80% sequence identity with the homologous SARS-CoV-2 S-protein region, making it a valuable tool for studying coronavirus host-cell entry mechanisms and screening for broad-spectrum inhibitors.

Research Area

Neuroscience

Images & Validation

Key Properties

TargetCholinesterase (ChE)
CAS Number882157-88-2
MW1315.51
FormulaC56H94N14O20S
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(O)=O |@@:53|

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
View Guide

SP 10 (orb1693740)

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