SPD304 dihydrochloride

SKU: orb1309068

Description

SPD304 dihydrochloride is a selective small molecule inhibitor of TNF-α, functioning by disrupting the active trimeric form of the cytokine with an IC50 of 22 µM. This compound is a valuable research tool for studying TNF-α signaling in cellular models of inflammation and autoimmune diseases.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	1049741-03-8
MW	620.53
Purity	99.25%
Formula	C₃₂H₃₄Cl₂F₃N₃O₂
SMILES	O=C1C2=C(OC=C1CN(CCN(CC3=CN(C4=C3C=CC=C4)C5=CC=CC(C(F)(F)F)=C5)C)C)C=C(C)C(C)=C2.Cl.Cl
Target	TNF
Solubility	DMSO:6.21 mg/mL (10.01 mM)

Bioactivity

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Target IC50	TNF-α:22 µM
In Vitro	The survivability of aHSCs is significantly rescued by SPD304 dihydrochloride (2 μM). The production of lipid hydroxides and intracellular GSH are increased as well. GA (75 μM) and SPD304 dihydrochloride (2 μM) downregulate TRADD (almost 2-fold) and p−RIP3 (1.4−fold) compared to GA and promote the activation of caspase 8. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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TNF-α, SPD 304, SPD 304 Dihydrochloride, SPD304, SPD-304, SPD304 Dihydrochloride, SPD304 dihydrochloride, SPD-304 Dihydrochloride, SPD-304 dihydrochloride, TNFα

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Compound Identifiers

PubChem CID

16079006 ↗

Key Properties

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No computed properties available.

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