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SR-318

SKU: orb1309065

Description

SR-318 is a potent and selective p38 MAPK inhibitor, with IC50 values of 5 nM and 32 nM for p38α and p38β, respectively. It effectively suppresses TNF-α release in whole blood (IC50 = 283 nM), making it a valuable tool for investigating inflammatory pathways in cellular and animal models of disease.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2413286-32-3
MW459.58
Purity99.74% (May vary between batches)
FormulaC27H33N5O2
SMILESNc1c(cnn1-c1ccccc1)C(=O)NCc1ccc(cc1)C(=O)NCCCC1CCCCC1
TargetTNF,p38 MAPK
SolubilityDMSO:125 mg/mL (271.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.7 mM)

Bioactivity

Target IC50
p38α:5 nM|p38α/β:6.11 μM|TNF-α:283 nM|p38β:32 nM
In Vitro
SR-318 is a potent and selective type-II p38α/β inhibitor, utilized as a chemical probe to target the inactive state of these p38 isoforms .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SR 318, SR318, SR-318, TNF-α, TNFR, TNF Receptor, whole, p38 MAPK, p38MAPK, p38α, p38α/β, p38β, Tumor Necrosis Factor Receptor, anti-inflammatory, anti-cancer, blood, Inhibitor, inhibit
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

SR-318 (orb1309065)

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Available Sizes

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2 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 100.00
5 mg
$ 100.00
10 mg
$ 130.00
25 mg
$ 220.00
50 mg
$ 330.00
100 mg
$ 460.00
200 mg
$ 640.00
DispatchUsually dispatched within 3-5 working days
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